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Current Multiple Myeloma Treatment Strategies with Novel Agents: A European Perspective

Ongoing studies are therefore aiming to further delineate mechanisms of MM pathogenesis within the bone marrow to identify novel agents with enhanced cytotoxicity and decreased drug resistance to improve patient outcome.


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Multiple Myeloma - A New Era of Treatment Strategies is devoted to contributions from eminent scientists providing readers with comprehensive accounts of the most recent developments in the field of MM research. It addresses the interests of scientists and clinical investigators in MM research as well as other fields of oncology, in which the microenvironment is believed to play an important role.

A Short History of Multiple Myeloma. Epidemiology and Etiology of Multiple Myeloma. Brenda M.

Front line treatment of elderly multiple myeloma in the era of novel a | BTT

Birmann, Brian C. Chiu, Kristin Muench, Catherine A. Suppan and Wendy Cozen. Genetic and Epigenetic Mechanisms in Multiple Myeloma.

Current Multiple Myeloma Treatment Strategies with Novel Agents: A European Perspective

Guideline to Multiple Myeloma Treatment Strategies. Klaus Podar, Jonathan L. Kaufmann, Jacob P.

Additionally, the important issue of maintenance treatment needs to be further investigated. These new and emerging therapies offer multiple effective treatment options for MM patients and greatly enhanced treatment strategies for clinicians. Keywords: multiple myeloma, elderly, bortezomib, thalidomide, revlimid, IMiDs, supportive care.

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Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4. In order to provide our website visitors and registered users with a service tailored to their individual preferences we use cookies to analyse visitor traffic and personalise content. Harousseau will then specifically focus on the changing role of autologous and allogeneic stem cell transplantation as part of new treatment regimens.

Front line treatment of elderly multiple myeloma in the era of novel agents

Drs Vallet and Raje will review the pathophysiology and treatment options of MM bone disease thereby identifying potential therapeutic alternatives to bisphosphonates. Lentzsch will then discuss the management of complications in MM and supportive treatment regimens.


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  • Finally, Dr. Kumar will summarize promising advanced clinical trials, which are likely to change once more MM treatment regimens in near future.

    Taken together, Section 2 aims to address the needs of clinicians who are looking for the rationale of up-to-date treatment guidelines in the day-to-day practice. In Section 3 exciting new preclinical results will be discussed. Chapters of this section will delineate the pathophysiologic key role of the BM microenvironment in MM Dr. Ribatti and Vacca , in particular.

    Publications by the members of NMSG's executive board:

    Moreover, Drs. Fulciniti and colleagues will discuss MM mouse models, their advantages and pitfalls in translational MM research. Based on mechanistic data presented in Section 3, Section 4 will finally summarize potential new therapeutic targets and derived new treatment strategies with focus on small molecules Drs.

    Podar and colleagues , as well as antibodies Dr. Sections 3 and 4 aim to predominantly address the interests of scientists and clinical investigators in the MM field. However, we hope and believe that our own and other studies of the pathophysiologic role of the tumor microenvironment, the identification of novel therapeutic targets, and the clinical introduction of derived agents in MM also may serve as a paradigm for translational research in other fields of oncology.

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