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The data used to support the findings of this study are available from the corresponding author upon request. The authors have declared that no competing interests exist. Europe PMC requires Javascript to function effectively. Recent Activity.

The present study is aimed at investigating the effects of galanin on the viability of cultured rat cortical astrocytes after oxidative stress induced by H2O2 and possible receptor and signaling mechanisms involved. Treatment of galanin had significant protective effects against H2O2-induced toxicity in the cultured cortical astrocytes. The snippet could not be located in the article text. This may be because the snippet appears in a figure legend, contains special characters or spans different sections of the article.

Mediators Inflamm. Published online May PMID: Corresponding author. Liang Li: nc. Received Mar 20; Accepted Apr This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract The neuropeptide galanin and its receptors have been found to have protective effects on neurons. Materials and Methods 2.

Culture of Rat Cortical Astrocytes Astrocyte cultures were prepared from the cerebral cortex of 1-day-old neonatal Sprague Dawley rats. Table 1 PCR primers. Open in a separate window.

Introduction

Table 2 qPCR primers. Results 3. Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. No Modulation Effects of Galanin on Levels of A1 transcripts in Cultured Cortical Astrocytes It has been reported that astrocytes could be transformed to A1-type reactive astrocytes, which contribute to neuron death [ 10 ]. Figure 6. Figure 7. Data Availability The data used to support the findings of this study are available from the corresponding author upon request.

Conflicts of Interest The authors have declared that no competing interests exist. References 1. Sofroniew M. Astrocytes: biology and pathology. Acta Neuropathologica. Astrocyte barriers to neurotoxic inflammation. Nature Reviews Neuroscience. Murphy-Royal C. Astroglial glutamate transporters in the brain: regulating neurotransmitter homeostasis and synaptic transmission.

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Galanin (Experientia Supplementum) - Hökfelt, Tomas [Editor] - Hardcover | eBay

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Liddelow S. Neurotoxic reactive astrocytes are induced by activated microglia. Tatemoto K. Galanin - a novel biologically active peptide from porcine intestine. FEBS Letters. Melander T. Distribution of galanin like immunoreactivity in the rat central nervous system.

Journal of Comparative Neurology. The galanin and galanin receptor subtypes, its regulatory role in the biological and pathological functions. Physiological Research. The Journal of Comparative Neurology. Neuropeptide and small transmitter coexistence: fundamental studies and relevance to mental illness. Frontiers in Neural Circuits. Hobson S.

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Basel, Switzerland: Springer; Galanin acts as a trophic factor to the central and peripheral nervous systems; pp. Experientia supplementum. Elliott-Hunt C.

Professor at the Karolinska Institutet, Sweden

Activation of the galanin receptor 2 GalR2 protects the hippocampus from neuronal damage. Journal of Neurochemistry. Endogenous galanin protects mouse hippocampal neurons against amyloid toxicity in vitro via activation of galanin receptor Journal of Alzheimer's Disease. Webling K. Aging and Disease. Priller J.

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Cultured astrocytes express functional receptors for galanin. Liu H. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Lang R. Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity.

Pharmacological Reviews. Galanin acts as a neuroprotective factor to the hippocampus. Cheng Y. Cui J. Galanin protects against intracellular amyloid toxicity in human primary neurons. Dowell J. Mechanisms of Nrf2 protection in astrocytes as identified by quantitative proteomics and siRNA screening. PLoS One. Ito J. Biochemical properties in membrane of rat astrocytes under oxidative stress. Brain Research.

Elmann A. Neurochemistry International. Hawes J. Galanin and galanin-like peptide modulate neurite outgrowth via protein kinase C-mediated activation of extracellular signal-related kinase. Goldstein, B. Pergamon Press, Oxford. Progress in Brain Research, Vol. Eds: T.